Signaling through LRP1: Protection from atherosclerosis and beyond
نویسندگان
چکیده
منابع مشابه
Signaling through LRP1: Protection from atherosclerosis and beyond.
The low-density lipoprotein receptor-related protein (LRP1) is a multifunctional cell surface receptor that belongs to the LDL receptor (LDLR) gene family and that is widely expressed in several tissues. LRP1 consists of an 85-kDa membrane-bound carboxyl fragment (β chain) and a non-covalently attached 515-kDa (α chain) amino-terminal fragment. Through its extracellular domain, LRP1 binds at le...
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Vascular smooth muscle cell (SMC) proliferation and migration are important events in the development of atherosclerosis. The low-density lipoprotein receptor-related protein (LRP1) mediates suppression of SMC migration induced by platelet-derived growth factor (PDGF). Here we show that LRP1 forms a complex with the PDGF receptor (PDGFR). Inactivation of LRP1 in vascular SMCs of mice causes PDG...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2011
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2010.09.018